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Fluorescent Organic Nanoaggregates for Selective Recognition of d ‐(−)‐Ribose in Biological Fluids and Oral Supplements
Author(s) -
Dey Nilanjan,
Bhattacharya Santanu
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703034
Subject(s) - ribose , fluorescence , monomer , chemistry , hydrogen bond , combinatorial chemistry , biophysics , biochemistry , photochemistry , polymer , molecule , organic chemistry , biology , enzyme , physics , quantum mechanics
Easily synthesizable, fluorescent, organic nanoaggregates have been utilized, for the first time, in the selective recognition of d ‐(−)‐ribose at pH 5.5 in water. In the self‐assembled form, the reactive sites of the monomer units can be properly organized to form an effective “recognition cleft” for ribose (limit of detection ≈23 μ m ), in which binding mainly occurs through a combination of hydrogen‐bonding and CH⋅⋅⋅π interactions. The degree of agglomeration shows a profound influence on the extent of ribose sensing. A reduction in the optical response (≈1.8‐fold) is observed when ribose is allowed to interact with nanoaggregates of smaller dimensions (a decrease in the hydrodynamic diameter from (≈212.7±10.2) to (≈44.6±3.5) nm). The protocol is also utilized for the estimation of ribose in human urine samples and oral supplements. Low‐cost paper strips have also been developed for rapid, on‐site detection of ribose without involving any sophisticated instruments or skilled personnel.