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Inside Cover: Oligosaccharide Sensing in Aqueous Media by Porphyrin–Curdlan Conjugates: A Prêt‐á‐Porter Rather Than Haute‐Couture Approach (Chem. Eur. J. 47/2017)
Author(s) -
Fukuhara Gaku,
Sasaki Mayuko,
Numata Munenori,
Mori Tadashi,
Inoue Yoshihisa
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702834
Subject(s) - acarbose , curdlan , porphyrin , chemistry , aqueous medium , aqueous solution , trimer , combinatorial chemistry , stereochemistry , nanotechnology , materials science , organic chemistry , polysaccharide , dimer , enzyme
Porphyrin–curdlan conjugates selectively bound tetrasaccharide acarbose, a drug for type‐2 diabetes, from mono‐ to hexasaccharides. The spectral range employed (>400 nm), high selectivity for acarbose, low detection limit (0.2 m m ), and broad dynamic range (0.2–45 m m ) make these sensors attractive for use in diabetes research, diagnosis, and therapy. Hence, the present prêt‐á‐porter approach, rather than haute‐couture one, combining a hydrogen‐bonding saccharide co‐aggregate component (curdlan) with a signal‐readout reporter (porphyrin) should be expandable to other sensing systems which are thought to be difficult to operate in aqueous media. More information can be found in the Full Paper by G. Fukuhara, Y. Inoue et al. on page 11272.