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A Simple Route to Strong Carbon‐13 NMR Signals Detectable for Several Minutes
Author(s) -
Roy Soumya S.,
Norcott Philip,
Rayner Peter J.,
Green Gary G. R.,
Duckett Simon B.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702767
Subject(s) - hyperpolarization (physics) , spin isomers of hydrogen , zeeman effect , nuclear magnetic resonance , induced polarization , polarization (electrochemistry) , magnetization , chemistry , magnetic field , nuclear magnetic resonance spectroscopy , hydrogen , physics , organic chemistry , quantum mechanics , electrical resistivity and conductivity
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from low sensitivity and limited nuclear spin memory lifetimes. Although hyperpolarization techniques increase sensitivity, there is also a desire to increase relaxation times to expand the range of applications addressable by these methods. Here, we demonstrate a route to create hyperpolarized magnetization in 13 C nuclear spin pairs that last much longer than normal lifetimes by storage in a singlet state. By combining molecular design and low‐field storage with para ‐hydrogen derived hyperpolarization, we achieve more than three orders of signal amplification relative to equilibrium Zeeman polarization and an order of magnitude extension in state lifetime. These studies use a range of specifically synthesized pyridazine derivatives and dimethyl p ‐tolyl phenyl pyridazine is the most successful, achieving a lifetime of about 190 s in low‐field, which leads to a 13 C‐signal that is visible for 10 minutes.