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Sequence Engineering to Control the Helix Handedness of Peptide Foldamers
Author(s) -
RudzińskaSzostak Ewa,
Berlicki Łukasz
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702730
Subject(s) - sequence (biology) , helix (gastropod) , peptide , foldamer , chemistry , crystallography , stereochemistry , biology , biochemistry , paleontology , snail
Peptide foldamers have been studied for over two decades and numerous sequence patterns have been shown to form well‐defined three‐dimensional arrangements in solution. In particular, helices of various geometries have been described. In this article, different concepts concerning the construction of helical foldameric peptides, for which the possibility of governing the sense of the formed helix was evidenced, are presented and discussed.