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Inside Back Cover: 2′β‐Fluoro‐Tricyclo Nucleic Acids (2′F‐tc‐ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation (Chem. Eur. J. 43/2017)
Author(s) -
Istrate Alena,
Katolik Adam,
Istrate Andrei,
Leumann Christian J.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702636
Subject(s) - nucleic acid , rnase h , rnase p , rna , dna , chemistry , duplex (building) , stereochemistry , furanose , cleavage (geology) , thermal stability , crystallography , biology , biochemistry , gene , ring (chemistry) , organic chemistry , paleontology , fracture (geology)
What a difference a fluorine makes when introduced into the 2′‐β‐position of the tricyclo‐DNA skeleton (2′F‐tc‐ANA). It steers the conformation of the furanose unit into an eastern conformation. Fully modified 2′F‐tc‐ANA shows enhanced binding to complementary RNA in the same way as parent tc‐DNA. Embedded in a 2′OMe‐RNA hybrid construct it enables RNaseH cleavage of a complementary RNA target, thus enhancing the application range of the tc‐DNA family as antisense agents. More information can be found in the Full Paper by C. J. Leumann et al. on page 10310.