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Nanoscale Metal–Organic Frameworks Decorated with Graphene Oxide for Magnetic Resonance Imaging Guided Photothermal Therapy
Author(s) -
Meng Jing,
Chen Xiujin,
Tian Yang,
Li Zhongfeng,
Zheng Qingfeng
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702573
Subject(s) - photothermal therapy , materials science , graphene , composite number , magnetic resonance imaging , nanoscopic scale , nanotechnology , biomedical engineering , composite material , radiology , medicine
Imaging‐guided photothermal therapy (PTT) provides an attractive way to treat cancer. A composite material of a nanoscale metal–organic framework (NMOF) and graphene oxide (GO) has been prepared for potential use in tumor‐guided PTT with magnetic resonance imaging (MRI). The NMOFs containing Fe 3+ were prefabricated with an octahedral morphology through a solvothermal reaction to offer a strong T 2 ‐weighted contrast in MRI. Then the NMOFs were decorated with GO nanosheets, which had good photothermal properties. After decoration, zeta‐potential characterization shows that the aqueous stability of the composite material is enhanced, UV/Vis and near‐infrared (NIR) spectra confirm that NIR absorption is also increased, and photothermal experiments reveal that the composite materials express higher photothermal conversion effects and conversion stability. The fabricated NMOF/GO shows low cytotoxicity, effective T 2 ‐weighted contrast of MRI, and positive PTT behavior for a tumor model in vitro. The performance of the composite NMOF/GO for MRI and PTT was also tested upon injection into A549 tumor‐bearing mice. The studies in vivo revealed that the fabricated NMOF/GO was efficient in T 2 ‐weighted imaging and ablation of the A549 tumor with low cytotoxicity, which implied that the prepared composite contrast agent was a potential multifunctional nanotheranostic agent.