Premium
Artificial Metallooxidases from Cyclodextrin Diacids
Author(s) -
Wang Bo,
Bols Mikael
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702530
Subject(s) - cyclodextrin , chemistry , catalysis , zinc , copper , dissociation (chemistry) , metal , polymer chemistry , dissociation constant , combinatorial chemistry , organic chemistry , biochemistry , receptor
Unprecedented simple artificial metalloenzymes were made from cyclodextrin diacids. Six α‐ and β‐cyclodextrin diacids were prepared and their metal‐binding and acid properties were investigated. The diacids formed fairly stable complexes with copper, zinc, and iron, with dissociation constants of 0.4–8×10 −4 m . The iron complexes were found to catalyse a Fenton‐like oxidation reaction of benzylic alcohols, which displayed Michaelis–Menten catalysis and rate accelerations up to 2700.