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Mild Cobalt(III)‐Catalyzed Allylative C−F/C−H Functionalizations at Room Temperature
Author(s) -
Zell Daniel,
Müller Valentin,
Dhawa Uttam,
Bursch Markus,
Presa Rubén Rubio,
Grimme Stefan,
Ackermann Lutz
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702528
Subject(s) - cobalt , catalysis , scope (computer science) , cleavage (geology) , substrate (aquarium) , chemistry , combinatorial chemistry , nanotechnology , stereochemistry , materials science , inorganic chemistry , organic chemistry , computer science , composite material , biology , ecology , fracture (geology) , programming language
Sustainable, cobalt‐catalyst enabled, synthetically significant C−F/C−H functionalizations were achieved with an ample substrate scope at an ambient temperature of 25 °C, thereby delivering perfluoroallylated heteroarenes. Detailed experimental and computational mechanistic studies on the C−F/C−H functionalizations provided strong support for a facile C−F cleavage.