A Consecutive C−H Functionalization Triggered by Oxidation of Active sp 3  C−H Bonds: Construction of 3,4‐Dihydroquinoline‐3‐one Derivatives | Zendy

Jia Xiaodong | Zendy; Hou Wentao | Zendy; Shao Yu | Zendy; Yuan Yu | Zendy; Chen Qian | Zendy; Li Pengfei | Zendy; Liu Xiaofei | Zendy; Ji Honghe | Zendy

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A Consecutive C−H Functionalization Triggered by Oxidation of Active sp 3 C−H Bonds: Construction of 3,4‐Dihydroquinoline‐3‐one Derivatives

Author(s) -

Jia Xiaodong,

Hou Wentao,

Shao Yu,

Yuan Yu,

Chen Qian,

Li Pengfei,

Liu Xiaofei,

Ji Honghe

Publication year - 2017

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201702497

Subject(s) - surface modification , chemistry , ring (chemistry) , carbon fibers , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , materials science , composite number , composite material

We report a consecutive C−H functionalization that constructs 3,4‐dihydroquinoline‐3‐one derivatives in high yields. This reaction is triggered by oxidation of active sp 3 C−H bonds of glycines and N ‐benzylanilines. In this radical mediated transformation, four sp 3 C−H bonds are functionalized efficiently, together with construction of one heterocyclic ring with a quaternary carbon center.

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