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Cu‐catalyzed Cascade Cyclization of Isothiocyanates, Alkynes, and Diaryliodonium Salts: Access to Diversely Functionalized Quinolines
Author(s) -
Khan Salman,
Volla Chandra M. R.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702364
Subject(s) - quinoline , annulation , chemistry , catalysis , combinatorial chemistry , cascade reaction , cascade , organic chemistry , chromatography
Herein, we report a copper‐catalyzed novel, highly efficient, and modular cascade annulation reaction for the synthesis of quinoline derivatives starting from easily available alkynes, isothiocyanates, and diaryliodonium salts. The reaction displayed excellent regioselectivities, when unsymmetrical alkynes were employed as partners, giving access to diversely functionalized quinolines in good to excellent yields for a wide range of functional groups.