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Direct C2‐Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt
Author(s) -
Tayu Masanori,
Nomura Kazuya,
Kawachi Koki,
Higuchi Kazuhiro,
Saito Nozomi,
Kawasaki Tomomi
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201702338
Subject(s) - indole test , iminium , sulfonium , chemistry , surface modification , reagent , salt (chemistry) , combinatorial chemistry , functional group , organic chemistry , catalysis , polymer
Abstract An indole core bearing a functional group on the C2 position is often found as a key structure in biologically active natural products and pharmaceuticals. Here, we report direct C2‐functionalization of indoles triggered by the formation of an iminium species generated from indole and a sulfonium reagent. The reaction proceeded under very mild conditions to give the corresponding C2‐substituted indole derivatives in good to high yields.