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A Nonmetal‐Containing Nitric Oxide Donor Activated with Single‐Photon Green Light
Author(s) -
Blangetti Marco,
Fraix Aurore,
Lazzarato Loretta,
Marini Elisabetta,
Rolando Barbara,
Sodano Federica,
Fruttero Roberta,
Gasco Alberto,
Sortino Salvatore
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701889
Subject(s) - nitric oxide , photoexcitation , nonmetal , green light , vasodilation , two photon excitation microscopy , photochemistry , chemistry , materials science , nanotechnology , optoelectronics , fluorescence , blue light , cardiology , optics , organic chemistry , medicine , physics , excited state , nuclear physics , metal
Using a facile synthetic route, an organic NO release agent based on a BODIPY light‐harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green‐light‐induced NO release.