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Back Cover: Accessing Structurally Diverse Near‐Infrared Cyanine Dyes for Folate Receptor‐Targeted Cancer Cell Staining (Chem. Eur. J. 39/2017)
Author(s) -
König Sandra G.,
Krämer Roland
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701748
Subject(s) - cyanine , folate receptor , fluorescence , chemistry , absorbance , cancer cell , conjugate , conjugated system , folic acid , photochemistry , combinatorial chemistry , biophysics , cancer , organic chemistry , chromatography , biology , optics , polymer , medicine , physics , mathematical analysis , mathematics , genetics
Expanding the bioimaging toolbox of NIR dyes : A series of structurally diverse indotricarbocyanines was prepared by one‐step Pd‐catalyzed C−C‐coupling reactions from a chlorinated precursor dye. Absorbance maxima, fluorescence brightness, and photostability are dependent on the structure of the dyes. Conjugation of the dyes to folic acid enables the selective visualization of cancer cells. Moreover, the dye structure affects the affinity of the conjugates to the folate receptors on the cells. More information can be found in the Full Paper by R. Krämer et al. on page 9306.