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Iodine‐Promoted Semmler–Wolff Reactions: Step‐Economic Access to meta ‐Substituted Primary Anilines via Aromatization
Author(s) -
Wang ShiKe,
You Xia,
Zhao DaYuan,
Mou NengJie,
Luo QunLi
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701712
Subject(s) - aromatization , catalysis , noble metal , iodine , primary (astronomy) , chemistry , combinatorial chemistry , inert gas , reaction conditions , organic chemistry , physics , astronomy
An atom‐ and step‐economic access to an array of unprotected meta ‐substituted primary anilines was disclosed using the Semmler–Wolff reaction, promoted by molecular iodine. Therein, noble metal catalysts and inert atmosphere are unnecessary while the forcing reaction conditions and the lengthy synthesis can be avoided. The synthetic utility of this approach is evident in the de novo syntheses of three bioactive molecules with good total yields.