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Instantaneous Conversion of [ 11 C]CO 2 to [ 11 C]CO via Fluoride‐Activated Disilane Species
Author(s) -
Taddei Carlotta,
Bongarzone Salvatore,
Gee Antony D.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701661
Subject(s) - disilane , chemistry , carbon monoxide , reagent , yield (engineering) , fluoride , radiochemistry , carbon dioxide , activated carbon , nuclear chemistry , inorganic chemistry , catalysis , organic chemistry , materials science , adsorption , silane , metallurgy
The development of a fast and novel methodology to generate carbon‐11 carbon monoxide ([ 11 C]CO) from cyclotron‐produced carbon‐11 carbon dioxide ([ 11 C]CO 2 ) mediated by a fluoride‐activated disilane species is described. This methodology allows up to 74 % conversion of [ 11 C]CO 2 to [ 11 C]CO using commercially available reagents, readily available laboratory equipment and mild reaction conditions (room temperature). As proof of utility, radiochemically pure [carbonyl‐ 11 C] N ‐benzylbenzamide was successfully synthesized from produced [ 11 C]CO in up to 74 % radiochemical yield (RCY) and >99 % radiochemical purity (RCP) in ≤10 min from end of [ 11 C]CO 2 delivery.
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