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Redox‐Neutral Dual Functionalization of Electron‐Deficient Alkenes
Author(s) -
Pettersson Fredrik,
Bergonzini Giulia,
Cassani Carlo,
Wallentin CarlJohan
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701589
Subject(s) - photoredox catalysis , radical , surface modification , redox , combinatorial chemistry , substrate (aquarium) , chemistry , intermolecular force , cascade , photochemistry , catalysis , dual role , organic chemistry , photocatalysis , molecule , oceanography , chromatography , geology
Visible‐light photoredox catalysis has been utilized in a new multicomponent reaction forming β‐functionalized δ‐diketones under mild conditions in an operationally convenient manner. Single‐electron reduction of in situ generated carboxylic acid derivatives forms acyl radicals that react further via 1,2‐acylalkylation of olefins in an intermolecular, three‐components cascade reaction, giving valuable synthetic entities from readily available starting materials. A diverse set of substrates has been used, demonstrating robust methodology with broad substrate scope.