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18 F‐Labeling of Sensitive Biomolecules for Positron Emission Tomography
Author(s) -
Krishnan Hema S.,
Ma Longle,
Vasdev Neil,
Liang Steven H.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701581
Subject(s) - biomolecule , bioconjugation , positron emission tomography , molecular imaging , pet imaging , biodistribution , positron , chemistry , radiochemistry , nanotechnology , nuclear medicine , medical physics , materials science , physics , medicine , biochemistry , nuclear physics , biology , in vivo , microbiology and biotechnology , in vitro , electron
Positron emission tomography (PET) imaging study of fluorine‐18 labeled biomolecules is an emerging and rapidly growing area for preclinical and clinical research. The present review focuses on recent advances in radiochemical methods for incorporating fluorine‐18 into biomolecules via “direct” or “indirect” bioconjugation. Recently developed prosthetic groups and pre‐targeting strategies, as well as representative examples in 18 F‐labeling of biomolecules in PET imaging research studies are highlighted.