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Inside Cover: Synthesis of ortho ‐Azophenols by Formal Dehydrogenative Coupling of Phenols and Hydrazines or Hydrazides (Chem. Eur. J. 36/2017)
Author(s) -
Esguerra Kenneth Virgel N.,
Lumb JeanPhilip
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701560
Subject(s) - phenols , nucleophile , cover (algebra) , formal synthesis , product (mathematics) , ideal (ethics) , sequence (biology) , combinatorial chemistry , chemistry , information transmission , catalysis , organic chemistry , computer science , mathematics , biochemistry , philosophy , engineering , mechanical engineering , computer network , geometry , epistemology
A synthesis of azophenols that interfaces the unrelated biosynthetic processes of melanogenesis and collagen formation into a one‐pot sequence is described. Azophenols possess ideal properties for fast information transmission in biological contexts. This study provides mild and selective conditions, overcoming a long‐standing challenge to couple nucleophilic phenols and hydrazines or hydrazides using O 2 as oxidant. The method highlights many benefits of bio‐inspired synthesis, including an earth‐abundant and readily available copper catalyst and water as the main by‐product. More information can be found in the Communication by J. P. Lumb and K. V. N Esguerra on page 8596.