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Synthesis of Magnetic‐Nanoparticle/Ansamitocin Conjugates—Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo
Author(s) -
Seidel Katja,
Balakrishnan Asha,
Alexiou Christoph,
Janko Christina,
Komoll RonjaMelinda,
Wang LiangLiang,
Kirschning Andreas,
Ott Michael
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701491
Subject(s) - semisynthesis , in vivo , in vitro , linker , chemistry , biophysics , cytotoxicity , superparamagnetism , nanoparticle , hyperthermia , magnetic hyperthermia , conjugate , drug delivery , cell growth , magnetic nanoparticles , materials science , nanotechnology , biochemistry , biology , magnetic field , magnetization , physics , microbiology and biotechnology , quantum mechanics , computer science , operating system , paleontology , mathematical analysis , mathematics
Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour‐selective drug delivery and release. It combines chemo‐ with thermal therapy. The linker‐modified toxin was prepared by a combination of biotechnology and semisynthesis. Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model. Biocompatibility studies for these magnetic‐nanoparticle/ansamitocin conjugates complement this work.