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A pH‐Responsive DNAsome from the Self‐Assembly of DNA–Phenyleneethynylene Hybrid Amphiphile
Author(s) -
Albert Shine K.,
Golla Murali,
Thelu Hari Veera Prasad,
Krishnan Nithiyanandan,
Varghese Reji
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701446
Subject(s) - amphiphile , dna , chemistry , random coil , self assembly , membrane , biophysics , stereochemistry , biochemistry , organic chemistry , polymer , circular dichroism , copolymer , biology
A pH‐responsive DNAsome derived from the amphiphilicity‐driven self‐assembly of DNA amphiphile containing C‐rich DNA sequence is reported. The acidification of DNAsome induces a structural change of C‐rich DNA from random coil to an i‐motif structure that triggers the disassembly of DNAsome and its subsequent morphological transformation into an open entangled network. The encapsulation of a hydrophobic guest into the membrane of DNAsome and its pH‐triggered release upon acidification of DNAsome is also demonstrated.