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Targeted Photodynamic Therapy with a Folate/Sensitizer Assembly Produced from Mesoporous Silica
Author(s) -
Zhou Chunfang,
Afonso Damien,
Valetti Sabrina,
Feiler Adam,
Cardile Venera,
Graziano Adriana C. E.,
Conoci Sabrina,
Sortino Salvatore
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701432
Subject(s) - singlet oxygen , mesoporous silica , porphyrin , covalent bond , mesoporous material , photodynamic therapy , aqueous solution , folate receptor , photochemistry , chemistry , folic acid , fluorescence , materials science , chemical engineering , catalysis , cancer cell , oxygen , organic chemistry , cancer , medicine , physics , quantum mechanics , engineering
A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso ‐tetrakis(4‐carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady‐state and time‐resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to the aqueous phase in the form of a non‐covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process. The FA/TCPP assembly exhibits dual color fluorescence in the visible region, good photosensitization capability of singlet oxygen, and enhanced photo‐induced mortality in KB cancer cells overexpressing folate receptor, if compared with the free components.