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Rationally Designed Solvatochromic Fluorescent Indoline Derivatives for Probing Mitochondrial Environment
Author(s) -
Pal Kaushik,
Koner Apurba Lal
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701425
Subject(s) - solvatochromism , fluorescence , bioconjugation , indoline , quantum yield , stokes shift , photochemistry , polarity (international relations) , thermal stability , chemistry , biophysics , materials science , nanotechnology , cell , biology , biochemistry , organic chemistry , optics , physics
A new class of solvatochromic, robust, and multifunctional fluorescent probes derived from indoline is presented. Specificity of mitochondria targeting was achieved and utilized for probing polarity under normal and apoptotic conditions. A large Stokes shift, high quantum yield, thermal, photochemical, and pH stability, tolerance to buffer compositions, and a bioconjugation tool‐kit make it a promising candidate for live‐cell fluorescence imaging.