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Paper‐Based Colorimetric Sensor System for High‐Throughput Screening of C−H Borylation
Author(s) -
Kim HanSung,
Eom Min Sik,
Han Min Su,
Lee Sunwoo
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701256
Subject(s) - borylation , benzene , chemistry , yield (engineering) , high throughput screening , chromatography , combinatorial chemistry , materials science , organic chemistry , biochemistry , alkyl , aryl , metallurgy
A paper‐based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B 2 Pin 2 ) and applied as a high‐throughput screening protocol in Ir‐catalyzed C−H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue‐violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B 2 Pin 2 . The extents of conversion of B 2 Pin 2 obtained from the PBCSS showed good correlation with those obtained from gas chromatography analysis. In addition, the modified conversion using blank data showed good correlation with the yield of products.