Premium
A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications
Author(s) -
Reja Shahi Imam,
Sharma Neetu,
Gupta Muskan,
Bajaj Payal,
Bhalla Vandana,
Parihar Ripu D.,
Ohri Puja,
Kaur Gurcharan,
Kumar Manoj
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201701124
Subject(s) - hydrogen sulfide , in vivo , fluorescence , in vitro , chemistry , biophysics , nanotechnology , materials science , biochemistry , biology , microbiology and biotechnology , organic chemistry , physics , sulfur , quantum mechanics
A fluorescein‐based fluorescent probe has been designed and synthesised that selectively detects H 2 S in aqueous medium, among various analytes tested. This fluorescein‐based fluorescent probe has also been successfully utilised for real‐time imaging of exo‐ and endogenously produced H 2 S in cancer cells and normal cells. Moreover, the probe can also detect H 2 S in the rat brain hippocampus at variable depths and in living nematodes.