A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications | Zendy

Reja Shahi Imam | Zendy; Sharma Neetu | Zendy; Gupta Muskan | Zendy; Bajaj Payal | Zendy; Bhalla Vandana | Zendy; Parihar Ripu D. | Zendy; Ohri Puja | Zendy; Kaur Gurcharan | Zendy; Kumar Manoj | Zendy

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A Highly Selective Fluorescent Probe for Detection of Hydrogen Sulfide in Living Systems: In Vitro and in Vivo Applications

Author(s) -

Reja Shahi Imam,

Sharma Neetu,

Gupta Muskan,

Bajaj Payal,

Bhalla Vandana,

Parihar Ripu D.,

Ohri Puja,

Kaur Gurcharan,

Kumar Manoj

Publication year - 2017

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201701124

Subject(s) - hydrogen sulfide , in vivo , fluorescence , in vitro , chemistry , biophysics , nanotechnology , materials science , biochemistry , biology , microbiology and biotechnology , organic chemistry , physics , sulfur , quantum mechanics

A fluorescein‐based fluorescent probe has been designed and synthesised that selectively detects H 2 S in aqueous medium, among various analytes tested. This fluorescein‐based fluorescent probe has also been successfully utilised for real‐time imaging of exo‐ and endogenously produced H 2 S in cancer cells and normal cells. Moreover, the probe can also detect H 2 S in the rat brain hippocampus at variable depths and in living nematodes.

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