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Back Cover: Conformational Analysis of an Antibacterial Cyclodepsipeptide Active against Mycobacterium tuberculosis by a Combined ROE and RDC Analysis (Chem. Eur. J. 24/2017)
Author(s) -
Fredersdorf Maic,
Kurz Michael,
Bauer Armin,
Ebert MarcOlivier,
Rigling Carla,
Lannes Laurie,
Thiele Christina Marie
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700694
Subject(s) - mycobacterium tuberculosis , chemistry , stereochemistry , dna , nuclear magnetic resonance spectroscopy , polymerase , insert (composites) , tuberculosis , biochemistry , materials science , medicine , pathology , composite material
Griselimycin (GM) and methylgriselimycin (MGM) are cyclic depsipeptides that inhibit the sliding clamp of DNA polymerase III of Mycobacterium tuberculosis and are therefore considered as potential anti‐tuberculosis drugs. Methylation increases both stability and activity of MGM compared to GM. The solution structure of MGM was determined using advanced NMR spectroscopy. A highly defined structural model of MGM was obtained, which shows related characteristics to GM bound to DNA polymerase III subunit‐beta. More information can be found in the Full Paper by C. M. Thiele et al. on page 5729 ff.