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Iron‐Catalyzed C−H Alkynylation through Triazole Assistance: Expedient Access to Bioactive Heterocycles
Author(s) -
Cera Gianpiero,
Haven Tobias,
Ackermann Lutz
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700587
Subject(s) - alkynylation , catalysis , chemistry , triazole , combinatorial chemistry , click chemistry , organic chemistry
Abstract Triazole assistance enabled the first iron‐catalyzed C−H alkynylation of arenes, heteroarenes, and alkenes. The modular TAM directing group set the stage for a sequential C−H alkynylation/annulation strategy with ample scope, enabling the iron‐catalyzed assembly of isoquinolones, pyridones, pyrrolones, and isoindolinones with high levels of chemo‐, site‐, and regioselectivity.