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Enantioselective Rauhut–Currier‐Type 1,6‐Conjugate Addition of Methyl Vinyl Ketone to para ‐Quinone Methides
Author(s) -
Kang TianChen,
Wu LuPing,
Yu QiWen,
Wu XinYan
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700520
Subject(s) - conjugate , methyl vinyl ketone , enantioselective synthesis , phosphine , catalysis , cyclohexane , ketone , amide , chemistry , organic chemistry , medicinal chemistry , mathematics , mathematical analysis
An unprecedented Rauhut–Currier‐type 1,6‐conjugate addition has been developed. With chiral cyclohexane‐based phosphine‐amide catalyst 3 h , the 1,6‐conjugate reaction has been achieved to produce chiral diarylmethine compounds in excellent yields (91–99 %) and enantioselectivities (92–98 % ee ).
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