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Inside Back Cover: Double‐Strand DNA Breaks Induced by Paracyclophane Gold(I) Complexes (Chem. Eur. J. 26/2017)
Author(s) -
Bestgen Sebastian,
Seidl Carmen,
Wiesner Thomas,
Zimmer Andreas,
Falk Martina,
Köberle Beate,
Austeri Martina,
Paradies Jan,
Bräse Stefan,
Schepers Ute,
Roesky Peter W.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700517
Subject(s) - hela , dna , cytotoxicity , chemistry , apoptosis , dna damage , cover (algebra) , cytotoxic t cell , stereochemistry , biophysics , double strand , in vitro , microbiology and biotechnology , biochemistry , biology , mechanical engineering , engineering
Gold(I) complexes of ClickPhos [2.2]paracyclophane ligands were systematically studied with respect to their cytotoxic properties. Their efficiency in cytotoxicity was investigated in HeLa, MCF7 and HCT116 cells displaying different mechanisms of action, which involve apoptosis, necrosis, and DNA damage. The gold‐based cytostatics induce double‐strand DNA breaks (DSB) as shown by H2AX phosphorylation at foci of DSBs. More information can be found in the Full Paper by U. Schepers, P. W. Roesky et al. on page 6315 ff.