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Glucose‐Responsive Supramolecular Vesicles Based on Water‐Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery
Author(s) -
Gao Lei,
Wang Tingting,
Jia Keke,
Wu Xuan,
Yao Chenhao,
Shao Wei,
Zhang Dongmei,
Hu XiaoYu,
Wang Leyong
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700345
Subject(s) - nanocarriers , supramolecular chemistry , drug delivery , insulin delivery , insulin , vesicle , chemistry , pillar , controlled release , nanotechnology , drug , combinatorial chemistry , diabetes mellitus , pharmacology , materials science , molecule , biochemistry , medicine , organic chemistry , endocrinology , type 1 diabetes , structural engineering , membrane , engineering
The stimuli‐responsive behavior of supramolecular nanocarriers is crucial for their potential applications as smart drug delivery systems. We hereby constructed a glucose‐responsive supramolecular drug delivery system based on the host–guest interaction between a water‐soluble pillar[5]arene ( WP5 ) and a pyridylboronic acid derivative ( G ) for insulin delivery and controlled release under physiological conditions. The approach represents the ideal treatment of diabetes mellitus. The drug loading and in vitro drug release experiments demonstrated that large molecular weight insulin could be encapsulated into the vesicles with high loading efficiency, which, to our knowledge, is the first example of small‐size supramolecular vesicles with excellent encapsulation capacity of a large protein molecule. Moreover, FITC‐labeled insulin was used to evaluate the release behavior of insulin, and it was demonstrated that high glucose concentration could facilitate the quick release of insulin, suggesting a smart drug delivery system for potential application in controlled insulin release only under hyperglycemic conditions. Finally, we demonstrated that these supramolecular nanocarriers have good cytocompatibility, which is essential for their further biomedical applications. The present study provides a novel strategy for the construction of glucose‐responsive smart supramolecular drug delivery systems, which has potential applications for the treatment of diabetes mellitus.