Premium
Taming a Vinyl Cation with a Simple Al(OTf) 3 Catalyst To Promote C−C Bond Cleavage
Author(s) -
Niggemann Meike,
Fu Liang,
Damsen Helena
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700282
Subject(s) - carbocation , catalysis , selectivity , chemistry , aryl , bond cleavage , combinatorial chemistry , photochemistry , medicinal chemistry , organic chemistry , alkyl
A detailed mechanistic investigation identified the stepwise nature of the 1,3‐aryl shift, which enables our recently disclosed Al 3+ ‐catalyzed insertion of unactivated alkynes into the sp 2 –sp 3 C−C bond of benzyl alcohols. The selectivity for the rearranged product was found to be induced by the continued coordination of the aluminum catalyst to the rearranging species, which is encouraged by a reversible background reaction. This participation of the catalyst beyond the ionization step is unique in the realm of carbocation driven reactions and opens up the possibility of a catalyst‐induced chiral induction in the future. Furthermore, the study represents a rare example of detailed mechanistic analysis of a reaction with a product selectivity that changes with increasing conversion.