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Back Cover: Alcohol‐Enhanced Cu‐Mediated Radiofluorination (Chem. Eur. J. 14/2017)
Author(s) -
Zischler Johannes,
Kolks Niklas,
Modemann Daniel,
Neumaier Bernd,
Zlatopolskiy Boris D.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700191
Subject(s) - cover (algebra) , alcohol , chemistry , combinatorial chemistry , organic chemistry , engineering , mechanical engineering
Alcohol is the solution : The potential of many 18 F‐labeled (hetero)aromatics for positron emission tomography (PET) remains underexploited, so the development and optimization of radiolabeling procedures remains a research area of considerable interest. It is shown herein that alcohol‐containing solvent systems give rise to unexpectedly enhanced copper‐mediated aromatic 18 F‐labeling, enabling rapid radiolabeling of a broad scope of boronic and stannyl substrates under general reaction conditions. Among others, this allows the direct synthesis of radiofluorinated indoles, phenols, and anilines from unprotected precursors. More information can be found in the Communication by B. Neumaier et al. on page 3251 ff.