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Designed Synthesis of Lipid‐Coated Polyacrylic Acid/Calcium Phosphate Nanoparticles as Dual pH‐Responsive Drug‐Delivery Vehicles for Cancer Chemotherapy
Author(s) -
Wang Xin,
Zhang Manjie,
Zhang Lingyu,
Li Lu,
Li Shengnan,
Wang Chungang,
Su Zhongmin,
Yuan Yue,
Pan Weisan
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700060
Subject(s) - polyacrylic acid , doxorubicin , drug delivery , nanocarriers , chemistry , drug , biocompatibility , cancer cell , lipid bilayer , cytotoxicity , pharmacology , biophysics , biochemistry , chemotherapy , in vitro , cancer , membrane , polymer , organic chemistry , medicine , surgery , biology
Herein, we report a facile strategy to prepare supported lipid‐bilayer‐coated polyacrylic acid/calcium phosphate nanoparticles (designated as PAA/CaP@SLB NPs) as a new dual pH‐responsive drug‐delivery platform for cancer chemotherapy. The synthesized PAA/CaP NPs exhibited both a high payload of doxorubicin (DOX) and dual pH‐responsive drug‐release properties. Additionally, the coated lipid bilayer had the ability to enhance the cellular uptake of PAA/CaP NPs without affecting the pH‐responsive drug release. Moreover, the blank PAA/CaP@SLB NPs exhibited excellent biocompatibility and the DOX‐loaded PAA/CaP@SLB NPs markedly increased the cellular accumulation of DOX and its cytotoxic effects on HepG‐2 cells. Furthermore, when used to evaluate the in vivo therapeutic efficacy in mice with the hepatocarcinoma cell line (H‐22), the DOX‐loaded PAA/CaP@SLB NPs exhibited superior inhibition of tumor growth compared with the free DOX group. Thus, PAA/CaP@SLB NPs are a promising drug‐delivery vehicle to increase the therapeutic efficacy of anticancer drugs.