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Cyclodextrin Nanoparticles Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Biomaterials
Author(s) -
Oliveri Valentina,
Bellia Francesco,
Vecchio Graziella
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700031
Subject(s) - cyclodextrin , polymer , chelation , 8 hydroxyquinoline , nanoparticle , chemistry , metal ions in aqueous solution , combinatorial chemistry , metal , polymer chemistry , materials science , nanotechnology , organic chemistry
Cyclodextrins are used as building blocks for the development of a host of polymeric biomaterials. The cyclodextrin polymers have found numerous applications as they exhibit unique features such as mechanical properties, stimuli responsiveness and drug loading ability. Notwithstanding the abundance of cyclodextrin polymers studied, metal‐chelating polymers based on cyclodextrins have been poorly explored. Herein we report the synthesis and the characterization of the first metal‐chelating β‐cyclodextrin polymer bearing 8‐hydroxyquinoline ligands. The metal ions (Cu 2+ or Zn 2+ ) can modulate the assembly of the polymer nanoparticles. Moreover, the protective activity of the new chelating polymer against self‐ and metal‐induced Aβ aggregation and free radical species are significantly higher than those of the parent compounds. These synergistic effects suggest that the incorporation of hydroxyquinoline moieties into a soluble β‐cyclodextrin polymer could represent a promising strategy to design multifunctional biomaterials.