z-logo
Premium
Enantioselective Total Synthesis and Structure Confirmation of the Natural Dimeric Tetrahydroxanthenone Dicerandrol C
Author(s) -
Ganapathy Dhandapani,
Reiner Johannes R.,
Valdomir Guillermo,
Senthilkumar Soundararasu,
Tietze Lutz F.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201700020
Subject(s) - enantioselective synthesis , enantiopure drug , total synthesis , absolute configuration , stereochemistry , chemistry , enantiomer , palladium , skeleton (computer programming) , catalysis , organic chemistry , biology , anatomy
The first enantioselective total synthesis of natural dicerandrol C ( 1 c ) as its enantiomer containing a dimeric tetrahydroxanthenone skeleton is described starting from the enantiopure chromane 6 which was obtained through a Wacker‐type cyclization with >99 %  ee . For the formation of the dimeric skeleton a palladium‐catalyzed Suzuki reaction was used. The synthesis allowed the confirmation of the absolute configuration of the dicerandrols.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here