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Frontispiece: Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2‐Indolylmethanols as 3 C Building Blocks
Author(s) -
Sun XiaoXue,
Zhang HongHao,
Li GuoHao,
He YingYing,
Shi Feng
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201684961
Subject(s) - enantioselective synthesis , regioselectivity , cycloaddition , catalysis , phosphoric acid , chemistry , combinatorial chemistry , organocatalysis , stereochemistry , organic chemistry
Asymmetric Catalysis Due to the great challenges in 2‐indolylmethanol‐involved enantioselective cycloadditions, 2‐indolylmethanols have scarcely been utilized for catalytic asymmetric cycloadditions. In their Communication on page 17526 ff., F. Shi and co‐workers demonstrate the first catalytic asymmetric [3+3] cycloaddition of 2‐indolylmethanols with azomethine ylides using a chiral phosphoric acid catalyst. Notably, this reaction proceeds with an abnormal regioselectivity, which provides easy access to enantioenriched tetrahydro‐γ‐carboline frameworks.