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Frontispiece: Biodegradable Oxamide‐Phenylene‐Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells
Author(s) -
Croissant Jonas G.,
Fatieiev Yevhen,
Julfakyan Khachatur,
Lu Jie,
Emwas AbdulHamid,
Anjum Dalaver H.,
Omar Haneen,
Tamanoi Fuyuhiko,
Zink Jeffrey I.,
Khashab Niveen M.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201684261
Subject(s) - materials science , mesoporous material , nanoparticle , mesoporous organosilica , drug delivery , oxamide , nanotechnology , biodegradation , nanocomposite , chemical engineering , mesoporous silica , chemistry , organic chemistry , polymer chemistry , engineering , catalysis
Nanotechnology Biodegradable hybrid materials that combine high porosity and drug payload without drug leakage are in high demand. In their Communication on page 14806 ff., N. M. Khashab and et al. report the first completely biodegradable mesoporous hybrid nanovectors in the presence of proteases. Oxamide‐phenylene‐based mesoporous organosilica nanoparticles were synthesized with oxamide functions to enable the biodegradability in the presence of trypsin. Exceptionally high payloads of drugs (up to 84 wt%) and a unique zero premature leakage without the pore capping were observed.