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Frontispiece: Mild and Copper‐Free Stereoselective Cyanation of gem ‐Difluoroalkenes by Using Benzyl Nitrile as a Cyanating Reagent
Author(s) -
Zhang Juan,
Xu Chengyuan,
Wu Wei,
Cao Song
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201682961
Subject(s) - cyanation , nitrile , reagent , stereoselectivity , chemistry , combinatorial chemistry , organic chemistry , copper , catalysis
Selective Synthesis Useful fluorinated alkenyl nitriles! An efficient and novel method for the stereoselective synthesis of fluorinated alkenyl nitriles via the cyanation of gem ‐difluoroalkenes using benzyl nitrile as a cyano source with the assistance of t BuOLi and air at room temperature was developed. The synthetic utility of the important fluorinated building blocks was demonstrated by preparation of several valuable geometrically pure multisubstituted alkenes. For more details, see the Communication by S. Cao et al. on page 9902 ff.