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Frontispiece: Manganese‐Mediated C−H Alkylation of Unbiased Arenes Using Alkylboronic Acids
Author(s) -
Castro Susana,
Fernández Juan J.,
Fañanás Francisco J.,
Vicente Rubén,
Rodríguez Félix
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201682761
Subject(s) - alkylation , manganese , chemistry , alkyl , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis
Alkylation The alkyl chain of boronic acids is transferred to simple unbiased arenes at the “manganese station” to get interesting alkylarenes. More precisely, manganese(III) acetate promotes the formal C−H alkylation of arenes with boronic acids as alkylating agents through a process where radicals seem to be involved. The possibility of accessing linear n ‐alkyl arenes by this method is particularly remarkable because traditional direct arene alkylation procedures (Friedel–Crafts alkylation) do not allow the synthesis of this particular type of compounds. For more details see the Communication by F. J. Fañanás, R. Vicente, F. Rodríguez et al. on page 9068 ff.