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Frontispiece: Simple and Efficient Ruthenium‐Catalyzed Oxidation of Primary Alcohols with Molecular Oxygen
Author(s) -
Ray Ritwika,
Chandra Shubhadeep,
Maiti Debabrata,
Lahiri Goutam Kumar
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201682662
Subject(s) - chemistry , catalysis , alcohol oxidation , ruthenium , redox , allylic rearrangement , primary (astronomy) , molecular oxygen , alcohol , oxygen , hydride , homogeneous catalysis , electron transfer , combinatorial chemistry , photochemistry , organic chemistry , hydrogen , physics , astronomy
Aerobic Oxidation Oxidative transformations utilizing molecular oxygen as the stoichiometric oxidant are of great importance in organic synthesis. Alcohol oxidation reactions that employ O 2 are scarce in homogeneous catalysis and mostly involve secondary alcohol oxidation. Moreover, catalytic systems employing O 2 as the “primary” oxidant, in the absence of any additive, are rare. As reported by R. Ray, S. Chandra, D. Maiti, and G. K. Lahiri in the Full Paper on page 8814 ff., an efficient Ru‐catalyzed oxidation protocol has been developed that enables smooth oxidation of a wide variety of primary, as well as secondary benzylic, allylic, heterocyclic, and aliphatic, alcohols with molecular oxygen as the primary oxidant, without any base or hydrogen‐ or electron‐transfer agents. Experimental evidence, including 18 O labeling and kinetic studies, suggested an oxo‐ruthenium pathway involving a two‐electron hydride transfer in the redox step.