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Frontispiece: Gd‐TEMDO: Design, Synthesis, and MRI Application
Author(s) -
Boltjes André,
Shrinidhi Annadka,
van de Kolk Kees,
Herdtweck Eberhardt,
Dömling Alexander
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201682261
Subject(s) - moiety , contrast (vision) , chelation , carboxylate , combinatorial chemistry , chemistry , metal , crystal structure , stereochemistry , computer science , crystallography , organic chemistry , artificial intelligence
Contrast Agents Herein, the efforts in developing a new class of contrast agents based on tetrazoles are described, which replace the carboxylate moiety. A comparable chelating behavior, as tetrazoles are bioisosteres of carboxylic acids, was expected. Furthermore, contrast enhancement in a variety of tissues should be retained. The model example of MRI contrast agents is Dotarem. In the Frontispiece, the Dotarem analogue TEMDO is presented. The importance of keeping the metal in the macrocyclic cage is highlighted by the chains surrounding the otherwise known coordination sites from the four amines and four tetrazolates. The cartoon of TEMDO is based on the crystal structure of the complex in solid state. In the paper, the MRI application of the Gd‐TEMDO complex in an animal model is demonstrated, showing indeed a contrast enhancement. For more details, see the Communication by A. Dömling et al. on page 7352 ff.