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Frontispiece: Chemoenzymatic Synthesis of Pleiogenone A: An Antiproliferative Trihydroxyalkylcyclohexenone Isolated from Pleiogynium timorense
Author(s) -
Froese Jordan,
Overbeeke Cameron,
Hudlicky Tomas
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201681861
Subject(s) - dihydroxylation , stereochemistry , benzoic acid , total synthesis , chemistry , combinatorial chemistry , computer science , enantioselective synthesis , organic chemistry , catalysis
Natural Products Pleiogenone A, which has been isolated from Pleiogynium timorense , has been synthesized for the first time. The synthesis confirms the previously reported structure as well as the absolute configuration. The route started with the enzymatic dihydroxylation of inexpensive and readily available benzoic acid by R. eutrophus B9. For more details, see the Full Paper by T. Hudlicky et al. on page 6180 ff. Jordan Froese and Dennis Ceci, both at Brock University, are acknowledged for the design of the Frontispiece.