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Frontispiece: Origin of the Regioselective Fatty‐Acid Hydroxylation versus Decarboxylation by a Cytochrome P450 Peroxygenase: What Drives the Reaction to Biofuel Production?
Author(s) -
Faponle Abayomi S.,
Quesne Matthew G.,
de Visser Sam P.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201681661
Subject(s) - decarboxylation , hydroxylation , regioselectivity , chemistry , fatty acid , cytochrome p450 , biofuel , organic chemistry , biochemistry , biology , enzyme , microbiology and biotechnology , catalysis
Biotechnology P450 peroxygenases react with long‐chain fatty acids to give two typical products, namely olefins and α‐ and β‐hydroxylated fatty acids. Terminal olefins are very useful products in biotechnology and could be used as biofuels, and hence optimizing the product distributions in favour of olefin products is important. The mechanisms that lead to the formation of these products are described for the first time and establish the factors that determine to the bifurcation pathways leading to olefins and hydroxylated fatty acids. The authors thank Priscila Aharonovich for her help with the background picture. For more details, see the Communication by S. P. de Visser et al. on page 5478 ff.