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Frontispiece: Gold‐Catalyzed Tandem Cycloisomerization–Halogenation of Chiral Homopropargyl Sulfonamides
Author(s) -
Shu Chao,
Li Long,
Shen CangHai,
Ruan PengPeng,
Liu ChaoYue,
Ye LongWu
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201680762
Subject(s) - cycloisomerization , halogenation , selectfluor , tandem , catalysis , chemistry , halogen , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , alkyl , composite material
Tandem Reactions Two novel gold‐catalyzed tandem cycloisomerization–halogenation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 3,3‐diiodopyrrolidin‐2‐ols and 3‐fluoropyrrolidin‐2‐ols were obtained in moderate to good yields with excellent stereocontrol of enantioselectivity and diastereoselectivity by using N ‐iodosuccinimide and Selectfluor as halogen source, respectively. For more details see the Full Paper by C. Shu, L.‐W. Ye et al. on page 2282 ff.