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Frontispiece: An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression
Author(s) -
Vomacka Jan,
Korotkov Vadim S.,
Bauer Bianca,
Weinandy Franziska,
Kunzmann Martin H.,
Krysiak Joanna,
Baron Oliver,
Böttcher Thomas,
LorenzBaath Katrin,
Sieber Stephan A.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201680562
Subject(s) - staphylococcus aureus , virulence , toxin , microbiology and biotechnology , chemistry , virulence factor , microbial toxins , bacteria , biology , stereochemistry , biochemistry , gene , genetics
Anti‐Virulence Strategy The agreement depicted in the figure is between humans, who, instead of killing bacterial cells, just reduce their arsenal of virulence factors, and Staphylococcus aureus which, as a reward, do not respond with resistance development. In their Full Paper on page 1622 ff., S. A. Sieber et al. report that the molecule represented in the middle and on the contract is one of the most powerful among a set of hydroxyamide derivatives to exhibit this remarkable bioactivity.