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Frontispiece: Triphenylphosphine‐Mediated Deoxygenative Reduction of CF 3 SO 2 Na and Its Application for Trifluoromethylthiolation of Aryl Iodides
Author(s) -
Yang Yi,
Xu Long,
Yu Siqi,
Liu Xiaoqiang,
Zhang Yu,
Vicic David A.
Publication year - 2016
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201680361
Subject(s) - reagent , aryl , chemistry , triphenylphosphine , combinatorial chemistry , organic chemistry , catalysis , alkyl
Versatility of Langlois′ Reagent A simple and cost‐effective method towards taming Langlois′ reagent for the synthesis of copper trifluoromethylthiolate complexes has been established. This chemistry highlights a novel liberation of the inherent CF 3 S skeleton of Langlois′ reagent under mild deoxygenative reduction conditions. The CuSCF 3 intermediate prepared this way can be used to generate several air‐stable [LCu(SCF 3 )] complexes as valuable trifluoromethylthiolating agents. Additionally, the CuSCF 3 intermediate can be directly employed for the trifluoromethylthiolation of (hetero)aryl iodides with operational simplicity and atomic efficiency. For more details, see the Communication by Y. Yang, D. A. Vicic et al. on page 858 ff.