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Why DNA Is a More Effective Scaffold than RNA in Nucleic Acid‐Based Asymmetric Catalysis—Supramolecular Control of Cooperative Effects
Author(s) -
Marek Jasmin J.,
Hennecke Ulrich
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201606043
Subject(s) - nucleic acid , rna , catalysis , ribozyme , dna , combinatorial chemistry , enantioselective synthesis , chemistry , supramolecular chemistry , biochemistry , organic chemistry , molecule , gene
Nucleic acids can form efficient hybrid catalysts for asymmetric catalysis upon binding of low‐molecular‐weight metal complexes. Up to now DNA has been the preferred nucleic acid component, while RNA was largely ignored. It is shown that despite RNA′s successful use in ribozymes, RNA is less suited for use in hybrid catalysts for asymmetric catalysis. A common dimethyl bipyridine copper complex does not form highly active and enantioselective hybrid catalysts with RNA due to the absence of synergistic effects between the copper complex and dsRNA.