Premium
Enantioselective Tandem Oxidation/Michael–Aldol Approaches to Tetrasubstituted Cyclohexanes
Author(s) -
Rairmal K.,
Joshi Harshit,
Jha Rupesh K.,
Singh Vinod K.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605999
Subject(s) - enantioselective synthesis , cyclohexanes , aldol reaction , chemistry , michael reaction , context (archaeology) , tandem , organic chemistry , stereochemistry , catalysis , paleontology , materials science , composite material , biology
Enantioselective tandem Michael–aldol and oxidative Michael–aldol approaches have been achieved for the formation of diversely substituted cyclohexanes in total regio‐, diastereo‐ and enantioselective fashion. The presence of nitro, hydroxy and keto groups in the product provides a wide scope for further structural transformations. Furthermore, the utility of the catalytic process is demonstrated in the context of enantioselective formal synthesis of ABT‐341, a DPP4 inhibitor.