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Cover Picture: Effects of Chlorination on the Tautomeric Equilibrium of 2‐Hydroxypyridine: Experiment and Theory (Chem. Eur. J. 15/2017)
Author(s) -
Calabrese Camilla,
Maris Assimo,
Uriarte Iciar,
Cocinero Emilio J.,
Melandri Sonia
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605977
Subject(s) - tautomer , cover (algebra) , chemistry , computational chemistry , thermodynamics , medicinal chemistry , engineering , physics , mechanical engineering
The prototropic tautomerism in 2‐hydroxypridine represents a model for the study of conformational and tautomeric equilibria. The stability of the different species is governed by the balance between electronic and resonance effects and can be greatly influenced by ring substitutions and the presence of solvents. In particular, chlorination in different ring positions and changes in solvent polarity cause a shift of the equilibrium, therefore changing the relative abundances between isomers. More information can be found in the Full Paper by E. J. Cocinero, S. Melandri, et al. on page 3595 ff.