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Inside Back Cover: Reactions Catalysed by a Binuclear Copper Complex: Relay Aerobic Oxidation of N ‐Aryl Tetrahydroisoquinolines to Dihydroisoquinolones with a Vitamin B1 Analogue (Chem. Eur. J. 13/2017)
Author(s) -
Liu Yuxia,
Wang Chao,
Xue Dong,
Xiao Miao,
Liu Jiao,
Li Chaoqun,
Xiao Jianliang
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605969
Subject(s) - iminium , copper , chemistry , catalysis , relay , redox , aryl , medicinal chemistry , combinatorial chemistry , polymer chemistry , photochemistry , organic chemistry , power (physics) , physics , alkyl , quantum mechanics
A novel relay catalytic system , consisting of a binuclear copper and a vitamin B1 analogue, allows for the aerobic oxidation of N ‐aryltetrahydroisoquinolines to dihydroisoquinolones under mild conditions. Mechanistic studies revealed that the copper catalyst oxidizes amines to the corresponding iminium salts, which are subsequently oxygenated to lactam products by reaction with the vitamin B1 analogue. More information can be found in the Full Paper by C. Wang, J. Xiao et al. on page 3062 ff.