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Back Cover: Structure–Activity Relationships in Salinomycin: Cytotoxicity and Phenotype Selectivity of Semi‐synthetic Derivatives (Chem. Eur. J. 9/2017)
Author(s) -
Borgström Björn,
Huang Xiaoli,
Hegardt Cecilia,
Oredsson Stina,
Strand Daniel
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201605778
Subject(s) - salinomycin , ionophore , selectivity , cytotoxicity , chemistry , stereochemistry , structure–activity relationship , phenotype , biochemistry , in vitro , gene , antibiotics , membrane , catalysis
The ionophore salinomycin exerts selective activity against cancer stem cells. Synthetic strategies for modification of the directly accessible functional groups of this structure are explored, and a set of activity domains are identified by biological assays. Acylation of the C20 hydroxy group gives enhanced activity and selectivity against putative CSCs; disruption of ion coordinating motifs was not tolerated. The picture shows JIMT‐1 cells with 3D models of salinomycin approaching. More information can be found in the Full Paper by D. Strand et al. on page 2077 ff.